Proteintech, 33045-1-AP, ARMC12 Polyclonal antibody

Size: 20ul / 150ul The ARMC12 (33045-1-AP) by Proteintech is a Polyclonal antibody targeting ARMC12 in WB, IP, ELISA applications with reactivity to human, mouse samples 33045-1-AP targets ARMC12 in WB, IP, ELISA applications and shows reactivity with human, mouse samples. Tested Applications Positive WB detected in: mouse testis tissue Positive IP detected in: mouse testis tissue Recommended dilution Western Blot (WB): WB : 1:500-1:1000 Immunoprecipitation (IP): IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate Background Information ARMC12 (Armadillo Repeat Containing 12) is a protein localized to the outer mitochondrial membrane and belongs to the protein family containing Armadillo repeat sequences. Its primary function is to act as a positive regulator of mitochondrial fission. Research indicates that ARMC12 interacts with core proteins involved in mitochondrial fission, such as the dynamin-related protein DRP1 and its receptor MFF, facilitating the proper assembly and localization of the mitochondrial fission complex on the mitochondrial surface, thereby precisely regulating the fission process. Mitochondrial fission is crucial for maintaining mitochondrial network homeostasis, energy metabolism, apoptosis, and autophagy. Consequently, dysfunction of ARMC12 is believed to be potentially associated with diseases related to abnormal mitochondrial morphology, such as neurodegenerative diseases, metabolic disorders, and cancer, making it an important subject of study in the field of mitochondrial dynamics. Specification Tested Reactivity: human, mouse Host / Isotype: Rabbit / IgG Class: Polyclonal Type: Antibody Immunogen: CatNo: Ag37979 Product name: Recombinant human C6orf81 protein Source: e coli. -derived, PGEX-4T Tag: GST Domain: 1-367 aa of BC033033 Sequence: MGKSIPQYLGQLDIRKSVVSLATGAGAIYLLYKAIKAGIKCKPPLCSNSPICIARECPGPGERALPQEAPAPEASAVGGPKGLAVERERHGRDSGELRRLLNSLECKQDEYAKSMILHSITRCVYLLEAEASACTTDDIVLLGYMLDDKDNSVKTQALNTLKAFSGIRKFRLKIQEHSIKVLELISTIWDTELHIAGLRLLNNLPLPDYVHPQLRRVMPALMEILQSDYILAQVQAVRLLSYLAQKNDLLYDILNCQVHSNFLNLFQPTQSGSLLYEVLVFAERLSEGRNAPHYHVVKWHYNEQSLHESLFGEESRLADRLLALVIHPEEDVQIQACKVIVSLQYPQDLRARPSSCQPSRSYFKNTE Predict reactive species Full Name: chromosome 6 open reading frame 81 Observed Molecular Weight: 37 kDa GenBank Accession Number: BC033033 Gene Symbol: C6orf81 Gene ID (NCBI): 221481 Conjugate: Unconjugated Form: Liquid Purification Method: Antigen affinity Purification UNIPROT ID: Q5T9G4 Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.