Proteintech, 65053-1-Ig, Anti-Human CD107b / LAMP2 (H4B4)

Size: 100ug / 500ug The CD107b / LAMP2 (65053-1-Ig) by Proteintech is a Monoclonal antibody targeting CD107b / LAMP2 in IF/ICC, FC (Intra) applications with reactivity to human samples 65053-1-Ig targets CD107b / LAMP2 in IF/ICC, FC (Intra) applications and shows reactivity with human samples. Tested Applications Positive IF/ICC detected in: MCF-7 cells, U-251 cells Positive FC (Intra) detected in: HeLa cells Recommended dilution Immunofluorescence (IF)/ICC: IF/ICC : 1:400-1:1600 Flow Cytometry (FC) (INTRA): FC (INTRA) : 0.2 ug per 10^6 cells in 100 μl suspension Background Information LAMP2 (CD107b) is a Lysosomal membrane glycoprotein. LAMP2 is extensively glycosylated with asparagine-linked oligosaccharides which protect it from intracellular proteolysis (PMID: 10521503). Although LAMP-2 is localized primarily in the endosome-lysosomal membrane of cells, it is also found on the plasma membrane under certain circumstances, e.g., after platelet activation, during granulocytic differentiation and activation, and in some tumor cells (PMID: 12221139). LAMP is involved in lysosomal stability and autophagy (PMID: 12221139). This glycoprotein provides selectins with carbohydrate ligands. LAMP2 may play a role in tumor cell metastasis (PMID 9426697). Specification Tested Reactivity: human Cited Reactivity: human Host / Isotype: Mouse / IgG1, kappa Class: Monoclonal Type: Antibody Immunogen: Human adherent peripheral blood cells Predict reactive species Full Name: lysosomal-associated membrane protein 2 Calculated Molecular Weight: 45 kDa GenBank Accession Number: BC002965 Gene Symbol: LAMP2 Gene ID (NCBI): 3920 ENSEMBL Gene ID: ENSG00000005893 RRID: AB_2881469 Conjugate: Unconjugated Form: Liquid Purification Method: Protein G purification UNIPROT ID: P13473 Storage Buffer: PBS with 0.09% sodium azide, pH 7.3. Storage Conditions: Store at 2-8°C. Stable for one year after shipment.