Proteintech, 65081-1-Ig, Anti-Human PD-L1/CD274 (29E.2A3)

Size: 100ug / 500ug The PD-L1/CD274 (65081-1-Ig) by Proteintech is a Monoclonal antibody targeting PD-L1/CD274 in FC applications with reactivity to human samples 65081-1-Ig targets PD-L1/CD274 in FC applications and shows reactivity with human samples. Tested Applications Positive FC detected in: PHA treated human PBMCs Recommended dilution Flow Cytometry (FC): FC : 0.2 ug per 10^6 cells in 100 μl suspension Background Information Programmed cell death ligand 1 (PD-L1, CD274, or B7-H1), is the first member of B7 family to be discovered. B7 family molecules are type I transmembrane proteins belonging to the immunoglobulin superfamily. In concert with their CD28 family receptors, the B7s are key regulators of the adaptive immune response. PD-L1 is suggested as a negative regulator of T and B cell, and plays important role in mediating tolerance of lymphocytes to self-antigens. It is also involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PD-1-independent manner. Specification Tested Reactivity: human Cited Reactivity: human Host / Isotype: Mouse / IgG2b, kappa Class: Monoclonal Type: Antibody Immunogen: Full length human PD-L1 Predict reactive species Full Name: CD274 molecule GenBank Accession Number: BC069381 Gene Symbol: PD-L1 Gene ID (NCBI): 29126 RRID: AB_2918384 Conjugate: Unconjugated Form: Liquid Purification Method: Affinity purification UNIPROT ID: Q9NZQ7 Storage Buffer: PBS with 0.09% sodium azide, pH 7.3. Storage Conditions: Store at 2-8°C. Stable for one year after shipment.