Proteintech, 65227-1-Ig, Anti-Mouse CD48 (HM48-1)

Size: 500ug The CD48 (65227-1-Ig) by Proteintech is a Monoclonal antibody targeting CD48 in FC applications with reactivity to mouse samples 65227-1-Ig targets CD48 in FC applications and shows reactivity with mouse samples. Tested Applications Positive FC detected in: mouse splenocytes Recommended dilution Flow Cytometry (FC): FC : 0.5 ug per 10^6 cells in 100 μl suspension Background Information Signaling lymphocytic activation molecule family 2 (SLAMF2, CD48) is an adhesion and costimulatory molecule expressed constitutively on most hematopoietic cells, particularly in antigen-presenting cells (APC). CD48 is expressed on all the hematopoietic cells, both in humans and mice, except for murine neutrophils and long-term HSC. CD48 exists as both a membrane-bound (mCD48) and a soluble (sCD48) form. CD48 can activate T cells, antigen-presenting cells and granulocytes, by binding to CD2 or bacterial FimH, and through cell intrinsic effects. Interactions between CD48 and its high-affinity ligand CD244 are more complex, with both stimulatory and inhibitory outcomes. CD48 expression is increased in autoimmunity and allergy diseases, and anti-CD48 monoclonal antibodies have been shown to attenuate experimental autoimmune encephalomyelitis. Specification Tested Reactivity: mouse Host / Isotype: Armenian Hamster / IgG Class: Monoclonal Type: Antibody Immunogen: Mouse T lymphoma MBL-2 Predict reactive species Full Name: CD48 antigen GenBank Accession Number: BC060977 Gene Symbol: Cd48 Gene ID (NCBI): 12506 RRID: AB_2935145 Conjugate: Unconjugated Form: Liquid Purification Method: Protein G purification UNIPROT ID: P18181 Storage Buffer: PBS with 0.09% sodium azide, pH 7.3. Storage Conditions: Store at 2-8°C. Stable for one year after shipment.