Proteintech, 65268-1-Ig, Anti-Human CD31 (WM-59)

Size: 100ug / 500ug The CD31 (65268-1-Ig) by Proteintech is a Monoclonal antibody targeting CD31 in IF/ICC, FC applications with reactivity to human samples 65268-1-Ig targets CD31 in IF/ICC, FC applications and shows reactivity with human samples. Tested Applications Positive IF/ICC detected in: HUVEC cells Positive FC detected in: human PBMCs Recommended dilution Immunofluorescence (IF)/ICC: IF/ICC : 1:500-1:2000 Flow Cytometry (FC): FC : 0.2 ug per 10^6 cells in 100 μl suspension Background Information CD31, also known as PECAM1 (Platelet endothelial cell adhesion molecule), is a member of the immunoglobulin gene superfamily of cell adhesion molecules. CD31 is a transmembrane glycoprotein that is highly expressed on the surface of the endothelium, making up a large portion of its intracellular junctions. It is also present on the surface of hematopoietic cells and immune cells including platelets, monocytes, neutrophils, natural killer cells, megakaryocytes and some types of T-cell (PMID: 9011572). As well as its role in cell-cell adhesion, CD31 functions as a signaling receptor, and is involved in important physiological events such as nitric oxide production, regulation of T-cell immunity and tolerance, leukocyte transendothelial migration and inflammation and angiogenesis (PMID: 21183735; 20978210; 17872453; 20634489). Specification Tested Reactivity: human Host / Isotype: Mouse / IgG1, kappa Class: Monoclonal Type: Antibody Immunogen: N/A Predict reactive species Full Name: platelet/endothelial cell adhesion molecule Calculated Molecular Weight: 83 kDa GenBank Accession Number: BC022512 Gene Symbol: CD31 Gene ID (NCBI): 5175 ENSEMBL Gene ID: ENSG00000261371 RRID: AB_2935139 Conjugate: Unconjugated Form: Liquid Purification Method: Affinity purification UNIPROT ID: P16284 Storage Buffer: PBS with 0.09% sodium azide, pH 7.3. Storage Conditions: Store at 2-8°C. Stable for one year after shipment.