Proteintech, 65295-1-Ig, Anti-Human CD63 (H5C6)

Size: 100ug The CD63 (65295-1-Ig) by Proteintech is a Monoclonal antibody targeting CD63 in FC applications with reactivity to human samples 65295-1-Ig targets CD63 in FC applications and shows reactivity with human samples. Tested Applications Positive FC detected in: thrombin-activated human peripheral blood platelets Recommended dilution Flow Cytometry (FC): FC : 0.2 ug per 10^6 cells in 100 μl suspension Background Information CD63 is a 30-60 kDa lysosomal membrane protein that belongs to the tetraspanin family. This protein plays many important roles in immuno-physiological functions. It mediates signal transduction events that play a role in the regulation of cell development, activation, growth, and motility. CD63 is expressed on activated platelets, thus it may function as a blood platelet activation marker. CD63 is a lysosomal membrane glycoprotein that is translocated to plasma membrane after platelet activation. The CD63 tetraspanin is highly expressed in the early stages of melanoma and decreases in advanced lesions, suggesting it as a possible suppressor of tumor progression. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Specification Tested Reactivity: human Host / Isotype: Mouse / IgG1, kappa Class: Monoclonal Type: Antibody Immunogen: Human splenic adherent cells Predict reactive species Full Name: CD63 molecule GenBank Accession Number: BC013017 Gene Symbol: CD63 Gene ID (NCBI): 967 Conjugate: Unconjugated Form: Liquid Purification Method: Affinity purification UNIPROT ID: P08962 Storage Buffer: PBS with 0.09% sodium azide, pH 7.3. Storage Conditions: Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment.