Proteintech, 65582-1-MR, Anti-Human CD11b (ICRF44) Mouse IgG2a Recombinant Antibody

Size: 100ug The CD11b (65582-1-MR) by Proteintech is a Recombinant antibody targeting CD11b in FC applications with reactivity to human samples 65582-1-MR targets CD11b in FC applications and shows reactivity with human samples. Tested Applications Positive FC detected in: human PBMCs Recommended dilution Flow Cytometry (FC): FC : 0.25 ug per 10^6 cells in 100 μl suspension Background Information Integrins are cell adhesion receptors that are heterodimers composed of non-covalently associated α and β subunits (PMID: 9779984). CD11b, also known as Integrin alpha M or CR3A, belongs to the integrin alpha chain family. CD11b forms an α/β heterodimer with CD18 (integrin β2). CD11b/CD18 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens (PMID: 9558116; 20008295). CD11b/CD18 is a receptor for the complement protein fragment iC3b, and is also a receptor for fibrinogen, factor X and ICAM1 (PMID: 2971974; 15485828). Specification Tested Reactivity: human Host / Isotype: Mouse / IgG2a Class: Recombinant Type: Antibody Immunogen: Rheumatoid synovial cells and human monocytes Predict reactive species Full Name: integrin, alpha M (complement component 3 receptor 3 subunit) Calculated Molecular Weight: 1152 aa, 127 kDa GenBank Accession Number: BC096346 Gene Symbol: CD11b Gene ID (NCBI): 3684 ENSEMBL Gene ID: ENSG00000169896 RRID: AB_3670334 Conjugate: Unconjugated Form: Liquid Purification Method: Protein A purification UNIPROT ID: P11215 Storage Buffer: PBS with 0.09% sodium azide, pH 7.3. Storage Conditions: Store at 2-8°C. Stable for one year after shipment.