Proteintech, 65583-1-MR, Anti-Human CD49b (AK7) Mouse IgG2a Recombinant Antibody

Size: 100ug The CD49b (65583-1-MR) by Proteintech is a Recombinant antibody targeting CD49b in FC applications with reactivity to human samples 65583-1-MR targets CD49b in FC applications and shows reactivity with human samples. Tested Applications Positive FC detected in: human peripheral blood platelets Recommended dilution Flow Cytometry (FC): FC : 0.25 ug per 10^6 cells in a 100 µl suspension Background Information CD49b, also known as alpha2 integrin, is a type I transmembrane glycoprotein which forms an adhesion molecule VLA-2 with beta1 integrin. CD49b is a receptor for many (extracellular) matrix and non-matrix molecules (PMID: 23847623). CD49b is expressed on numerous cell types including platelets, activated T cells, B cells, and monocytes. CD49b activation skews NK cell effector function to a phenotype that exhibits elevated IFN-γ production with a concomitant inhibition of motility and cytolytic function (PMID: 32971468, 32762681). The Anti-Human CD49b antibody, clone AK7, is derived from Human platelets. Specification Tested Reactivity: human Host / Isotype: Mouse / IgG2a Class: Recombinant Type: Antibody Immunogen: Human platelets Predict reactive species Full Name: integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) Calculated Molecular Weight: 126 kDa GenBank Accession Number: NM_002203 Gene Symbol: Integrin alpha 2 Gene ID (NCBI): 3673 Conjugate: Unconjugated Form: Liquid Purification Method: Protein A purification UNIPROT ID: P17301 Storage Buffer: PBS with 0.09% sodium azide, pH 7.3. Storage Conditions: Store at 2-8°C. Stable for one year after shipment.