Proteintech, 65591-1-MR, Anti-Human CD21 (BU32) Mouse IgG2a Recombinant Antibody

Size: 100ug The CD21 (65591-1-MR) by Proteintech is a Recombinant antibody targeting CD21 in FC applications with reactivity to Human samples 65591-1-MR targets CD21 in FC applications and shows reactivity with Human samples. Tested Applications Positive FC detected in: human PBMCs Recommended dilution Flow Cytometry (FC): FC : 0.25 ug per 10^6 cells in 100 μl suspension Background Information CD21, also known as complement receptor type 2 (CR2), complement C3d receptor, and Epstein-Barr virus receptor, is a transmembrane protein that contains a small cytoplasmic domain, a transmembrane region and an extracellular domain consisting of 15 tandem short consensus repeat sequences (PMID: 6230668; 2551147). It is expressed on B cells, follicular dendritic cells, thymocytes and a subset of peripheral T cells (PMID: 26119182). CD21 binds complement fragments C3d, C3dg and iC3b and acts as a receptor for the Epstein-Barr virus (PMID: 7753047). On B cells, together with CD19 and CD81, CD21 forms a complex that functions as a co-receptor to the BCR (PMID: 7542009). It is involved in B cells activation and functions. Specification Tested Reactivity: Human Host / Isotype: Mouse / IgG2a Class: Recombinant Type: Antibody Immunogen: N/A Predict reactive species Full Name: complement component (3d/Epstein Barr virus) receptor 2 Calculated Molecular Weight: 1092 aa, 119 kDa GenBank Accession Number: BC136394 Gene Symbol: CD21 Gene ID (NCBI): 1380 ENSEMBL Gene ID: ENSG00000117322 RRID: AB_3670340 Conjugate: Unconjugated Form: Liquid Purification Method: Protein A purification UNIPROT ID: P20023 Storage Buffer: PBS with 0.09% sodium azide, pH 7.3. Storage Conditions: Store at 2-8°C. Stable for one year after shipment.