Proteintech, 65594-1-MR, Anti-Human LRP1 (5A6) Mouse IgG2a Recombinant Antibody

Size: 100ug The LRP1 (65594-1-MR) by Proteintech is a Recombinant antibody targeting LRP1 in FC applications with reactivity to human samples 65594-1-MR targets LRP1 in FC applications and shows reactivity with human samples. Tested Applications Positive FC detected in: U-87 MG cells Recommended dilution Flow Cytometry (FC): FC : 0.25 ug per 10^6 cells in a 100 µl suspension Background Information LRP1 (Prolow-density lipoprotein receptor-related protein 1), also known as A2MR, APOER and CD91, is a type I transmembrane protein that belongs to the LDLR family. LRP1 is synthesized as a transmembrane glycosylated precursor of 600 kDa, and is subsequently cleaved to generate a large 515-kDa N-terminal extracellular subunit and an 85-kDa C-terminal transmembrane subunit, which are noncovalently associated with one another (PMID: 2112085; 8546712). LRP1 is a multifunctional receptor involved in the clearance of a large number of diverse ligands and modulating various cellular processes. LRP1 is implicated in conditions such as atherosclerosis, cancer and neurodegenerative diseases (PMID: 28381441). Specification Tested Reactivity: human Host / Isotype: Mouse / IgG2a Class: Recombinant Type: Antibody Immunogen: Full length native protein (purified) Predict reactive species Full Name: low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor) Calculated Molecular Weight: 505 kDa GenBank Accession Number: BC045107 Gene Symbol: LRP1 Gene ID (NCBI): 4035 Conjugate: Unconjugated Form: Liquid Purification Method: Protein A purification UNIPROT ID: Q07954 Storage Buffer: PBS with 0.09% sodium azide, pH 7.3. Storage Conditions: Store at 2-8°C. Stable for one year after shipment.