Proteintech, 65606-1-MR, Anti-Rat CD11b/c (OX42) Mouse IgG2a Recombinant Antibody

Size: 100ug The CD11b/c (65606-1-MR) by Proteintech is a Recombinant antibody targeting CD11b/c in FC applications with reactivity to rat samples 65606-1-MR targets CD11b/c in FC applications and shows reactivity with rat samples. Tested Applications Positive FC detected in: rat bone marrow cells Recommended dilution Flow Cytometry (FC): FC : 0.25 ug per 10^6 cells in 100 μl suspension Background Information Integrins are cell adhesion receptors that are heterodimers composed of non-covalently associated α and β subunits (PMID: 9779984). CD11b (integrin alpha M or CR3A) and CD11c (integrin alpha X) are members of the integrin alpha chain family and can form α/β heterodimers with CD18 (integrin β2). CD11b/CD18 is a receptor for the complement protein fragment C3bi, and is also a receptor for fibrinogen, factor X, and ICAM1 (PMID: 2971974; 15485828). CD11c/CD18 acts as a receptor for fibrinogen and is important in monocyte adhesion and chemotaxis (PMID: 1671533). The OX-42 antibody recognizes a common epitope shared between CD11b and CD11c. It binds to C3bi receptor and is known to block C3bi binding (PMID: 3512425; 8449218). Specification Tested Reactivity: rat Host / Isotype: Mouse / IgG2a Class: Recombinant Type: Antibody Immunogen: Rat peritoneal macrophages Predict reactive species Full Name: integrin alpha M Calculated Molecular Weight: 127 kDa GenBank Accession Number: NM_012711 Gene Symbol: CD11b Gene ID (NCBI): 25021 RRID: AB_3670353 Conjugate: Unconjugated Form: Liquid Purification Method: Protein A purification UNIPROT ID: Q9JI30 Storage Buffer: PBS with 0.09% sodium azide, pH 7.3. Storage Conditions: Store at 2-8°C. Stable for one year after shipment.