Proteintech, 65632-1-MR, Anti-Human CD155/PVR (SKII.4) Mouse IgG2a Recombinant Antibody

Size: 100ug The CD155/PVR (65632-1-MR) by Proteintech is a Recombinant antibody targeting CD155/PVR in FC applications with reactivity to human samples 65632-1-MR targets CD155/PVR in FC applications and shows reactivity with human samples. Tested Applications Positive FC detected in: human PBMCs Recommended dilution Flow Cytometry (FC): FC : 0.25 ug per 10^6 cells in 100 μl suspension Background Information CD155, also known as PVR, is a type I transmembrane glycoprotein in the immunoglobulin superfamily. It contains three extracellular immunoglobulin-like domains, D1-D3, of which D1 is recognized by the virus. Mature human CD155 consists of a 323 amino acid extracellular domain with one N-terminal V-type and two C2-type Ig-like domains, a 24 amino acid transmembrane segment, and a 50 amino acid cytoplasmic tail. CD155 is thought to play a role in adhesion by interaction with the ECM component vitronectin as well as a role in NK killing of tumor cells. CD155 binds to two receptors of NK cells, CD96 and CD226, and accumulates at cell-cell contact sites, leading to the formation of mature immune synapses between NK cells and target cells. CD155 serves as the entry receptor for poliovirus and thereby mediates human susceptibility to poliovirus infection. Specification Tested Reactivity: human Host / Isotype: Mouse / IgG2a Class: Recombinant Type: Antibody Immunogen: SK-N-AS human neuroblastoma cells Predict reactive species Full Name: poliovirus receptor Calculated Molecular Weight: 45 kDa GenBank Accession Number: BC015542 Gene Symbol: CD155/PVR Gene ID (NCBI): 5817 RRID: AB_3670370 Conjugate: Unconjugated Form: Liquid Purification Method: Protein A purification UNIPROT ID: P15151 Storage Buffer: PBS with 0.09% sodium azide, pH 7.3. Storage Conditions: Store at 2-8°C. Stable for one year after shipment.