Proteintech, 68853-7-Ig, CLCC1 Monoclonal antibody

Size: 20ul / 150ul The CLCC1 (68853-7-Ig) by Proteintech is a Monoclonal antibody targeting CLCC1 in WB, ELISA applications with reactivity to human samples 68853-7-Ig targets CLCC1 in WB, ELISA applications and shows reactivity with human samples. Tested Applications Positive WB detected in: COLO 320 cells, HepG2 cells, hTERT-RPE1 cells, HeLa cells, K-562 cells, FaDu cells, SiHa cells, SCaBER cells, MG-63 cells, MDA-MB-468 cells Recommended dilution Western Blot (WB): WB : 1:5000-1:50000 Background Information CLCC1, also known as MCLC, is a transmembrane protein that localizes to intracellular compartments, including endoplasmic reticulum (ER), and it functions as a chloride channel (PMID: 11279057). It has been shown that loss of CLCC1 results in ER Stress, misfolded protein accumulation, and neurodegeneration (PMID: 25698737). CLCC1 forms homomultimer in the ER membrane and is a pore-forming component of an anion channel. Studies found that disruption of ER ion homeostasis maintained by CLCC1 is one of the causes of neurodegenerative diseases, such as ALS (amyotrophic lateral sclerosis) (PMID: 37142673). Specification Tested Reactivity: human Host / Isotype: Mouse / IgG1 Class: Monoclonal Type: Antibody Immunogen: CatNo: Ag24682 Product name: Recombinant human CLCC1 protein Source: e coli. -derived, PET28a Tag: 6*His Domain: 315-501 aa of BC002939 Sequence: GPESEPPQALRPRDRRRQEEIDYRPDGGAGDADFHYRGQMGPTEQGPYAKTYEGRREILRERDVDLRFQTGNKSPEVLRAFDVPDAEAREHPTVVPSHKSPVLDTKPKETGGILGEGTPKESSTESSQSAKPVSGQDTSGNTEGSPAAEKAQLKSEAAGSPDQGSTYSPARGVAGPRGQDPVSSPCG Predict reactive species Full Name: chloride channel CLIC-like 1 Calculated Molecular Weight: 551 aa, 62 kDa Observed Molecular Weight: 50-60 kDa GenBank Accession Number: BC002939 Gene Symbol: CLCC1 Gene ID (NCBI): 23155 RRID: AB_3670441 Conjugate: Unconjugated Form: Liquid Purification Method: Protein G purification UNIPROT ID: Q96S66 Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.