Proteintech, 69006-1-Ig, NeutraKine® IL-12/IL-23 p40 Mouse McAb

Size: 25ug / 100ug The NeutraKine® IL-12/IL-23 p40 (69006-1-Ig) by Proteintech is a Monoclonal antibody targeting NeutraKine® IL-12/IL-23 p40 in Neutralization, ELISA applications with reactivity to human samples 69006-1-Ig targets NeutraKine® IL-12/IL-23 p40 in Neutralization, ELISA applications and shows reactivity with human samples. Background Information IL-12 and IL-23 are heterodimeric cytokines that share a common p40 subunit (PMID: 11114383). IL-12 is composed of the IL-12 p40 subunit linked to the IL-12 p35 subunit, and the heterodimer signals through the IL-12 receptor (IL-12R), which comprises the IL-12Rβ1 and IL-12Rβ2 subunits. IL-23 is composed of the IL-23 p19 subunit and the IL-12 p40 (IL-12/23p40) subunit, which signals through IL-23R and IL-12Rβ1 (PMID: 11114383; 26121196 ). IL-12/IL-23 p40 also exists as a monomer and as a homodimer which can act as a potent IL-12 antagonist (PMID: 8958912; 18783467). IL-12/IL-23 p40 is produced by antigen-presenting cells, such as dendritic cells (DCs), monocytes, macrophages, neutrophils and, to a lesser extent, B cells (PMID: 20476918).This antibody can be used to neutralize the bioactivity of IL-12/IL-23 p40. Specification Tested Reactivity: human Host / Isotype: Mouse / IgG1 Class: Monoclonal Type: Antibody Immunogen: Recombinant Protein Predict reactive species Full Name: interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) Calculated Molecular Weight: 328 aa, 37 kDa GenBank Accession Number: BC067498 Gene Symbol: IL12B Gene ID (NCBI): 51561,3593 RRID: AB_2882924 Conjugate: Unconjugated Form: Lyophilized Powder Purification Method: Protein G purification UNIPROT ID: P29460 Storage Buffer: Sterile PBS, pH 7.4. Endotoxin: <0.1 EU/μg Reconstitution: This product was lyophilized from a 0.2 μm filtered solution in PBS. Reconstitute at 1.0 mg/mL in sterile H2O before use. Stability and Storage: Lyophilized antibodies are stable for 1 year from the date of receipt if stored between (-20°C) and (-80°C). Upon reconstitution we recommend that the solution can be stored at (4°C) for short term or at (-20°C) to (-80°C) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products.