Proteintech, 80867-1-RR, LAG-3/CD223 Recombinant monoclonal antibody

Size: 20ul / 100ul The LAG-3/CD223 (80867-1-RR) by Proteintech is a Recombinant antibody targeting LAG-3/CD223 in WB, ELISA applications with reactivity to human, mouse samples 80867-1-RR targets LAG-3/CD223 in WB, IF, ELISA applications and shows reactivity with human, mouse samples. Tested Applications Positive WB detected in: CTLL-2 cells Recommended dilution Western Blot (WB): WB : 1:1000-1:8000 Background Information LAG-3, also known as CD223, is an immune checkpoint molecule that regulates both T-cell activation and homeostasis. LAG-3 is expressed on activated T cells, NK cells, regulatory T cells, and plasmacytoid dendritic cells. It is a CD4-related molecule that binds MHC class II. LAG-3 plays an important role in modulating T cell expansion and function, and blockade of LAG-3 with monoclonal antibodies can augment T cell function. (PMID: 15634887; 21086108; 28783703) Specification Tested Reactivity: human, mouse Cited Reactivity: human, mouse Host / Isotype: Rabbit / IgG Class: Recombinant Type: Antibody Immunogen: Recombinant protein Predict reactive species Full Name: lymphocyte-activation gene 3 Calculated Molecular Weight: 57 kDa Observed Molecular Weight: 60 kDa GenBank Accession Number: NM_002286 Gene Symbol: LAG-3 Gene ID (NCBI): 3902 RRID: AB_2918917 Conjugate: Unconjugated Form: Liquid Purification Method: Protein A purification UNIPROT ID: P18627 Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.