Proteintech, 84384-5-RR, CD89 Recombinant monoclonal antibody

Size: 20ul / 100ul The CD89 (84384-5-RR) by Proteintech is a Recombinant antibody targeting CD89 in WB, ELISA applications with reactivity to human samples 84384-5-RR targets CD89 in WB, ELISA applications and shows reactivity with human samples. Tested Applications Positive WB detected in: A549 cells, HL-60 cells, K-562 cells, U-937 cells, Jurkat cells Recommended dilution Western Blot (WB): WB : 1:1000-1:8000 Background Information FcαRI (CD89) is a member of the Fc receptor immunoglobulin superfamily, constitutively expressed on cells of the myeloid lineage like neutrophils, eosinophils, monocytes macrophages, and platelets (PMID: 28103138). CD89 expression and activation are increased in human blood phagocytes following bacterial infection, together with increased expression and association of FcRγ with CD89 (PMID: 34756952). CD89 binds both subclasses of IgA (IgA1 and IgA2) with moderate affinity, but also binds other molecules such as TfR1, C-reactive protein and bacterial ligands. CD89 represents an effective target molecule for immunotherapy mediated by bispecific antibodies (PMID: 37081893). Specification Tested Reactivity: human Host / Isotype: Rabbit / IgG Class: Recombinant Type: Antibody Immunogen: Recombinant Protein Predict reactive species Full Name: Fc fragment of IgA, receptor for Calculated Molecular Weight: 287 aa, 32 kDa Observed Molecular Weight: 65-70 kDa GenBank Accession Number: BC027953 Gene Symbol: CD89 Gene ID (NCBI): 2204 RRID: AB_3671920 Conjugate: Unconjugated Form: Liquid Purification Method: Protein A purfication UNIPROT ID: P24071 Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.