Proteintech, 84695-1-RR, Integrin alpha 11 Recombinant monoclonal antibody

Size: 20ul / 100ul The Integrin alpha 11 (84695-1-RR) by Proteintech is a Recombinant antibody targeting Integrin alpha 11 in WB, ELISA applications with reactivity to human, mouse samples 84695-1-RR targets Integrin alpha 11 in WB, ELISA applications and shows reactivity with human, mouse samples. Tested Applications Positive WB detected in: SH-SY5Y cells, Neuro-2a cells, HeLa cells, A549 cells Recommended dilution Western Blot (WB): WB : 1:500-1:2000 Background Information The integrins are a superfamily of cell adhesion receptors that bind to extracellular matrix ligands, cell-surface ligands, and soluble ligands (PMID: 17543136). They are transmembrane αβ heterodimers and at least 24 distinct integrin heterodimers are formed by the combination of 18 α and eight β known subunits (PMID: 17543136; 20029421). In addition to mediating cell adhesion, integrins also play important roles in modulating signal transduction pathways that control cellular responses including migration, proliferation, differentiation, and apoptosis (PMID:19118207). Integrin alpha 11 (ITGA11) combines with the beta 1 subunit (ITGB1, CD29) to form a cell-surface receptor for collagen. This receptor is involved in cell migration and collagen reorganization on mesenchymal nonmuscle cells (PMID: 11518510). It is also involved in the regulation of myofibroblast phenotypic differentiation during fibrotic diseases (PMID: 29147013). Specification Tested Reactivity: human, mouse Host / Isotype: Rabbit / IgG Class: Recombinant Type: Antibody Immunogen: Peptide Predict reactive species Full Name: integrin, alpha 11 Calculated Molecular Weight: 133 kDa Observed Molecular Weight: 170 kDa GenBank Accession Number: NM_001004439 Gene Symbol: ITGA11 Gene ID (NCBI): 22801 RRID: AB_3672111 Conjugate: Unconjugated Form: Liquid Purification Method: Protein A purfication UNIPROT ID: Q9UKX5 Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.