Proteintech, 86858-1-RR, CAMK2B Recombinant monoclonal antibody

Size: 20ul / 100ul The CAMK2B (86858-1-RR) by Proteintech is a Recombinant antibody targeting CAMK2B in WB, ELISA applications with reactivity to human, mouse, rat samples 86858-1-RR targets CAMK2B in WB, ELISA applications and shows reactivity with human, mouse, rat samples. Tested Applications Positive WB detected in: U-251 cells, SH-SY5Y cells, Neuro-2a cells, C6 cells, rat brain tissue, mouse brain tissue, fetal human brain tissue Recommended dilution Western Blot (WB): WB : 1:5000-1:50000 Background Information CAMK2B(Calcium/calmodulin-dependent protein kinase type II subunit beta ), also named CAM2, CAMK2, and CAMKB, belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, and CaMK subfamily. It is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. CAMK2B is a member of the NMDAR signaling complex in excitatory synapses, it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity. It plays a distinct role in the induction of anergy in T lymphocytes, by differential regulation of IL10 and IL2 gene transcription suggesting MEF2A as a molecular target that can integrate different calcium signals(PMID:22578382). This protein has 8 isoforms produced by alternative splicing with a molecular weight between 50 kDa and 73 kDa. This antibody may have cross-reaction with CAMK2A/D/G due to the high homology. Specification Tested Reactivity: human, mouse, rat Host / Isotype: Rabbit / IgG Class: Recombinant Type: Antibody Immunogen: CatNo: Ag2119 Product name: Recombinant human CAMK2B protein Source: e coli. -derived, PGEX-4T Tag: GST Domain: 1-315 aa of BC019070 Sequence: MATTVTCTRFTDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITAHEALKHPWVCQRSTVASMMHRQETVECLKKFNARRKLKGAILTTMLATRNFS Predict reactive species Full Name: calcium/calmodulin-dependent protein kinase II beta Calculated Molecular Weight: 503 aa, 56 kDa Observed Molecular Weight: 50-70 kDa GenBank Accession Number: BC019070 Gene Symbol: CaMKII beta Gene ID (NCBI): 816 Conjugate: Unconjugated Form: Liquid Purification Method: Protein A purification UNIPROT ID: Q13554 Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.