Proteintech, 87291-1-RR, Phospho-EGFR (Thr693) Recombinant monoclonal antibody

Size: 20ul / 100ul The Phospho-EGFR (Thr693) (87291-1-RR) by Proteintech is a Recombinant antibody targeting Phospho-EGFR (Thr693) in WB, ELISA applications with reactivity to human samples 87291-1-RR targets Phospho-EGFR (Thr693) in WB, ELISA applications and shows reactivity with human samples. Tested Applications Positive WB detected in: EGF treated A431 cells Recommended dilution Western Blot (WB): WB : 1:5000-1:50000 Background Information Epidermal growth factor receptor (EGFR) is a member of the receptor tyrosine kinase (RTK) family and plays a critical role in a wide variety of cellular functions, including proliferation, differentiation and apoptosis. Phospho-EGFR (Thr693) is a phosphorylated form of the epidermal growth factor receptor (EGFR) at the threonine 693 residue. This phosphorylation event is significant as it is involved in the activation of EGFR signaling pathways. EGFR is known to be a transcriptional co-activator for several cancer-promoting genes, including cyclin D1, nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2). (PMID: 34295309) Some scientists call EGFR Thr693 as EGFR Thr669, the site where the signaling peptide is removed. Specification Tested Reactivity: human Host / Isotype: Rabbit / IgG Class: Recombinant Type: Antibody Immunogen: Peptide Predict reactive species Full Name: epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) Observed Molecular Weight: 150-180 kDa GenBank Accession Number: NM_005228 Gene Symbol: EGFR Gene ID (NCBI): 1956 Conjugate: Unconjugated Form: Liquid Purification Method: Protein A purification UNIPROT ID: P00533 Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.