Proteintech, 98048-1-RR, Anti-Human uPAR/CD87 Rabbit Recombinant Antibody

Size: 100ug The uPAR/CD87 (98048-1-RR) by Proteintech is a Recombinant antibody targeting uPAR/CD87 in IF/ICC, FC applications with reactivity to human samples 98048-1-RR targets uPAR/CD87 in IF/ICC, FC applications and shows reactivity with human samples. Tested Applications Positive IF/ICC detected in: HeLa cells Positive FC detected in: PMA treated U-937 cells Recommended dilution Immunofluorescence (IF)/ICC: IF/ICC : 1:200-1:800 Flow Cytometry (FC): FC : 0.25 ug per 10^6 cells in 100 μl suspension Background Information uPAR, also known as CD87, is a highly glycosylated, GPI-anchored membrane protein. In addition to the membrane-anchored form, uPAR is released from the plasma membrane by cleavage of the GPI anchor and can be found as a soluble form (suPAR). uPAR contains three homologous domains (D1-D3) of which the N-terminal one (D1) represents the uPA-binding domain. After binding to uPAR, uPA cleaves plasminogen, generating the active protease plasmin which is involved in a wide variety of physiologic and pathologic processes. In addition to regulating proteolysis, uPAR has important function in cell adhesion, migration and proliferation. Studies reveal that uPAR expression is elevated during inflammation and tissue remodeling and in many human cancers, in which it frequently indicates poor prognosis. (PMID 20027185; 12461559) Specification Tested Reactivity: human Host / Isotype: Rabbit / IgG Class: Recombinant Type: Antibody Immunogen: Recombinant protein Predict reactive species Full Name: PLAUR Calculated Molecular Weight: 37 kDa GenBank Accession Number: NM_002659.4 Gene Symbol: uPAR Gene ID (NCBI): 5329 RRID: AB_3672195 Conjugate: Unconjugated Form: Liquid Purification Method: Protein A purfication UNIPROT ID: Q03405-1 Storage Buffer: PBS with 0.09% sodium azide, pH 7.3. Storage Conditions: Store at 2-8°C. Stable for one year after shipment.