Proteintech, 98144-1-RR, Anti-Human IGF1R/CD221 Rabbit Recombinant Antibody

Size: 100ug The IGF1R/CD221 (98144-1-RR) by Proteintech is a Recombinant antibody targeting IGF1R/CD221 in FC applications with reactivity to human samples 98144-1-RR targets IGF1R/CD221 in FC applications and shows reactivity with human samples. Tested Applications Positive FC detected in: human peripheral blood granulocytes Recommended dilution Flow Cytometry (FC): FC : 0.25 ug per 10^6 cells in 100 μl suspension Background Information IGF1R, also named as CD221, is a receptor tyrosine kinase which mediates actions of INS-like growth factor 1 (IGF1). IGF1R binds IGF1 with high affinity and IGF2 and INS with a lower affinity, the activated IGF1R is involved in cell growth and survival control. It is crucial for tumor transformation and survival of malignant cells. IGF1R is translated as ~220 kDa pro-receptors (PMID: 33969359). IGF1R is a heterotetrameric receptor, composed of two alpha subunits (~130 kDa) and two beta subunits (~100-120 kDa) (PMID: 6279656). Both the alpha and beta subunits are synthesized from a single mRNA precursor. The precursor is then glycosylated, proteolytically cleaved, and crosslinked by cysteine bonds. Specification Tested Reactivity: human Host / Isotype: Rabbit / IgG Class: Recombinant Type: Antibody Immunogen: Recombinant Protein Predict reactive species Full Name: IGF I receptor Calculated Molecular Weight: 1367 aa, 155 kDa GenBank Accession Number: BC113612 Gene Symbol: IGF1R Gene ID (NCBI): 3480 RRID: AB_3672290 Conjugate: Unconjugated Form: Liquid Purification Method: Protein A purfication UNIPROT ID: P08069 Storage Buffer: PBS with 0.09% sodium azide, pH 7.3. Storage Conditions: Store at 2 - 8°C. Stable for one year after shipment.