Proteintech, 98244-1-RR, Anti-Human FGFR2/CD332 Rabbit Recombinant Antibody

Size: 100ug The FGFR2/CD332 (98244-1-RR) by Proteintech is a Recombinant antibody targeting FGFR2/CD332 in FC applications with reactivity to human samples 98244-1-RR targets FGFR2/CD332 in FC applications and shows reactivity with human samples. Tested Applications Positive FC detected in: Transfected HEK-293T cells Recommended dilution Flow Cytometry (FC): FC : 0.25 ug per 10^6 cells in 100 μl suspension Background Information FGFR2 (Fibroblast growth factor receptor 2), also known as CD332, is a tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration, and apoptosis. Ligand binding leads to the activation of several signaling pathways, such as RAS, MAPK1/ERK2, MAPK3/ERK1, and the MAP Kinase signaling pathway, as well as the AKT1 signaling pathway. Mutations in the gene of FGFR2 are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Specification Tested Reactivity: human Host / Isotype: Rabbit / IgG Class: Recombinant Type: Antibody Immunogen: Recombinant protein Predict reactive species Full Name: fibroblast growth factor receptor 2 Calculated Molecular Weight: 92kd GenBank Accession Number: NM_000141.4 Gene Symbol: FGFR2 Gene ID (NCBI): 2263 Conjugate: Unconjugated Form: Liquid Purification Method: Protein A purfication UNIPROT ID: P21802 Storage Buffer: PBS with 0.09% sodium azide, pH 7.3. Storage Conditions: Store at 2 - 8°C. Stable for one year after shipment.