Proteintech, 98253-1-RR, Anti-Human CD30 Ligand/TNFSF8 Rabbit Recombinant Antibody

Size: 100ug The CD30 Ligand/TNFSF8 (98253-1-RR) by Proteintech is a Recombinant antibody targeting CD30 Ligand/TNFSF8 in FC applications with reactivity to human samples 98253-1-RR targets CD30 Ligand/TNFSF8 in FC applications and shows reactivity with human samples. Tested Applications Positive FC detected in: PMA and ionomycin treated human PBMCs Recommended dilution Flow Cytometry (FC): FC : 0.25 ug per 10^6 cells in 100 μl suspension Background Information CD30 Ligand (CD30L), also named as TNFSF8 or CD153, is a type II transmembrane protein that belongs to the tumor necrosis factor (TNF) superfamily (PMID: 8391931). It is expressed on the surface of activated T cells, B cells, monocytes, macrophages, eosinophils, neutrophils, and mast cells (PMID: 26090498). CD30L interacts with its receptor, CD30, which is a cell surface protein expressed on a small subset of activated T and B lymphocytes, and a variety of lymphoid neoplasms, with the highest expression in classical Hodgkin lymphoma and anaplastic large cell lymphomas (PMID: 28885612). The CD30/CD30L signaling is involved in pleiotropic downstream effects including differentiation, cell survival and death, NFkB activation, and production of cytokines (PMID: 38534788). Specification Tested Reactivity: human Host / Isotype: Rabbit / IgG Class: Recombinant Type: Antibody Immunogen: Recombinant protein Predict reactive species Full Name: tumor necrosis factor (ligand) superfamily, member 8 Calculated Molecular Weight: 234 aa, 26 kDa GenBank Accession Number: BC093630 Gene Symbol: TNFSF8 Gene ID (NCBI): 944 Conjugate: Unconjugated Form: Liquid Purification Method: Protein A purfication UNIPROT ID: P32971 Storage Buffer: PBS with 0.09% sodium azide, pH 7.3. Storage Conditions: Store at 2 - 8°C. Stable for one year after shipment.