Proteintech, 98523-2-RR, Anti-Human TNFRSF21/DR6 Rabbit Recombinant Antibody

Size: 100ug The TNFRSF21/DR6 (98523-2-RR) by Proteintech is a Recombinant antibody targeting TNFRSF21/DR6 in FC applications with reactivity to human samples 98523-2-RR targets TNFRSF21/DR6 in FC applications and shows reactivity with human samples. Tested Applications Positive FC detected in: A431 cells, Transfected CHO cells Recommended dilution Flow Cytometry (FC): FC : 0.25 ug per 10^6 cells in a 100 µl suspension Background Information TNFRSF21 (also known as DR6 or CD358) is an orphan receptor of the tumor necrosis factor (TNF) receptor superfamily. It controls cell death and differentiation in a cell-autonomous manner in different cell types including neurons, oligodendrocytes, endothelial cells, and immune cells (PMID: 29459438). DR6 has been shown to activate NF-κB and JNK, and induce cell apoptosis (PMID: 9714541). DR6 interacts with TRADD, which is known to mediate signal transduction of TNF receptors. It has been reported that APP binds DR6 to trigger axon pruning and neuron death via distinct caspases, indicating that DR6 might be involved in Alzheimer's disease (PMID: 19225519). Specification Tested Reactivity: human Host / Isotype: Rabbit / IgG Class: Recombinant Type: Antibody Immunogen: CatNo: Eg2718 Product name: Recombinant Human TNFRSF21/DR6 protein (rFc Tag)(HPLC verified) Source: mammalian cells -derived, V37 Tag: C-rFc Domain: 42-349 aa of NM_014452.5 Sequence: QPEQKASNLIGTYRHVDRATGQVLTCDKCPAGTYVSEHCTNTSLRVCSSCPVGTFTRHENGIEKCHDCSQPCPWPMIEKLPCAALTDRECTCPPGMFQSNATCAPHTVCPVGWGVRKKGTETEDVRCKQCARGTFSDVPSSVMKCKAYTDCLSQNLVVIKPGTKETDNVCGTLPSFSSSTSPSPGTAIFPRPEHMETHEVPSSTYVPKGMNSTESNSSASVRPKVLSSIQEGTVPDNTSSARGKEDVNKTLPNLQVVNHQQGPHHRHILKLLPSMEATGGEKSSTPIKGPKRGHPRQNLHKHFDINEH Predict reactive species Full Name: tumor necrosis factor receptor superfamily, member 21 Calculated Molecular Weight: 72 kDa GenBank Accession Number: NM_014452.5 Gene Symbol: DR6 Gene ID (NCBI): 27242 Conjugate: Unconjugated Form: Liquid Purification Method: Protein A purification UNIPROT ID: O75509 Storage Buffer: PBS with 0.09% sodium azide, pH 7.3. Storage Conditions: Store at 2 - 8°C. Stable for one year after shipment.