Proteintech, 98602-3-RR, Anti-Human TRPM7 Rabbit Recombinant Antibody

Size: 100ug The TRPM7 (98602-3-RR) by Proteintech is a Recombinant antibody targeting TRPM7 in IHC, FC applications with reactivity to human samples 98602-3-RR targets TRPM7 in IHC, FC applications and shows reactivity with human samples. Tested Applications Positive IHC detected in: human tonsillitis tissueNote: suggested antigen retrieval withTE buffer pH 9.0;(*) Alternatively, antigen retrieval may be performed withcitrate buffer pH 6.0 Positive FC detected in: HepG2 cells Recommended dilution Immunohistochemistry (IHC): IHC : 1:500-1:2000 Flow Cytometry (FC): FC : 0.25 ug per 10^6 cells in a 100 µl suspension Background Information Transient receptor potential melastatin 7 (TRPM7), along with the closely related TRPM6, are unique channels that have dual operations: cation permeability and kinase activity. In contrast to the limited tissue distribution of TRPM6, TRPM7 is widely expressed among tissues and is therefore implicated in a variety of cellular functions physiologically and pathophysiologically. The discovery of TRPM7's unique structure imparting dual ion channel and kinase activities shed light onto novel and peculiar biological functions, such as Mg2+ homeostasis, cellular Ca2+ flickering, and even intranuclear transcriptional regulation by a cleaved kinase domain translocated to nuclei. Specification Tested Reactivity: human Host / Isotype: Rabbit / IgG Class: Recombinant Type: Antibody Immunogen: Peptide Predict reactive species Full Name: transient receptor potential cation channel, subfamily M, member 7 Calculated Molecular Weight: 213 kDa GenBank Accession Number: NM_017672 Gene Symbol: TRPM7 Gene ID (NCBI): 54822 Conjugate: Unconjugated Form: Liquid Purification Method: Protein A purification UNIPROT ID: Q96QT4 Storage Buffer: PBS with 0.09% sodium azide, pH 7.3. Storage Conditions: Store at 2 - 8°C. Stable for one year after shipment.