Proteintech, 98686-2-RR, Anti-Human CRHR1 Rabbit Recombinant Antibody

Size: 100ug The CRHR1 (98686-2-RR) by Proteintech is a Recombinant antibody targeting CRHR1 in FC applications with reactivity to human samples 98686-2-RR targets CRHR1 in FC applications and shows reactivity with human samples. Tested Applications Positive FC detected in: Transfected CHO-K1 cells Recommended dilution Flow Cytometry (FC): FC : 0.25 ug per 10^6 cells in a 100 µl suspension Background Information Corticotropin-releasing hormone (CRH, also known as Corticotropin-releasing factor, CRF) is a 41 amino acid peptide hormone and a key regulator of the stress response. CRH and the related urocortin peptides (UCN, UCN2 and UCN3) mediate their actions through two mammalian receptor subtypes, CRHR1 and CRHR2 (PMID: 23863939). CRHR1 (also known as CRFR1) exhibits high affinity towards CRH and UCN but low affinity towards UCN2 and no affinity towards UCN3 (PMID: 22684850). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Widely distributed throughout the brain, CRHR1 critically controls behavioral adaptation to stress and is causally linked to emotional disorders (PMID: 21885734). Alternative splicing results in multiple transcript variants encoding distinct isoforms of CRHR1. Specification Tested Reactivity: human Host / Isotype: Rabbit / IgG Class: Recombinant Type: Antibody Immunogen: Peptide Predict reactive species Full Name: corticotropin releasing hormone receptor 1 Calculated Molecular Weight: 48 kDa GenBank Accession Number: NM_004382 Gene Symbol: CRHR1 Gene ID (NCBI): 1394 Conjugate: Unconjugated Form: Liquid Purification Method: Protein A purification UNIPROT ID: P34998 Storage Buffer: PBS with 0.09% sodium azide, pH 7.3. Storage Conditions: Store at 2 - 8°C. Stable for one year after shipment.