Proteintech, 98745-1-RR, Anti-Human CCR4 Rabbit Recombinant Antibody

Size: 100ug The CCR4 (98745-1-RR) by Proteintech is a Recombinant antibody targeting CCR4 in FC applications with reactivity to human samples 98745-1-RR targets CCR4 in FC applications and shows reactivity with human samples. Tested Applications Positive FC detected in: human PBMCs Recommended dilution Flow Cytometry (FC): FC : 0.25 ug per 10^6 cells in a 100 µl suspension Background Information CC chemokine receptor 4 (CCR4) is important for regulating immune balance and is known to be expressed selectively on Th2 cells and Treg cells. Expression of CCR4 by tumor cells is associated with skin involvement, but CCR4 also has an important role in normal and tumor immunity (PMID: 16952304). CCR4+ adult T-cell leukemia/lymphoma is an example of the former phenomenon, and Hodgkin lymphoma of the latter, for which an almost identical immunopathogenesis has been reported in many types of cancer (PMID: 21044233, 12485447). Specification Tested Reactivity: human Host / Isotype: Rabbit / IgG Class: Recombinant Type: Antibody Immunogen: unknow Predict reactive species Full Name: chemokine (C-C motif) receptor 4 Gene Symbol: CCR4 Gene ID (NCBI): 1233 Conjugate: Unconjugated Form: Liquid Purification Method: Protein A purification UNIPROT ID: P51679 Storage Buffer: PBS with 0.09% sodium azide, pH 7.3. Storage Conditions: Store at 2 - 8°C. Stable for one year after shipment.