Proteintech, 98747-1-RR, Anti-Rat TLR4 Rabbit Recombinant Antibody

Size: 100ug The TLR4 (98747-1-RR) by Proteintech is a Recombinant antibody targeting TLR4 in FC applications with reactivity to rat samples 98747-1-RR targets TLR4 in FC applications and shows reactivity with rat samples. Tested Applications Positive FC detected in: NR8383 cells Recommended dilution Flow Cytometry (FC): FC : 25 ug per 10^6 cells in a 100 µl suspension Background Information TLR4, also known as CD284, belongs to the Toll-like receptor family. It is a type I transmembrane protein consisting of an extracellular leucine-rich repeat region, a helix transmembrane domain, and an intracellular Toll-IL-1 receptor domain. TLR4 functions as a pattern recognition receptor recognizing pathogen- and damage-associated molecular patterns (PAMPs and DAMPs) to induce innate immune responses via downstream signaling pathways. It interacts with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). TLR4 acts via MYD88, TIRAP, and TRAF6, leading to NF-kB activation, cytokine secretion, and the inflammatory response. Specification Tested Reactivity: rat Host / Isotype: Rabbit / IgG Class: Recombinant Type: Antibody Immunogen: unknow Predict reactive species Full Name: toll-like receptor 4 Gene Symbol: Tlr4 Gene ID (NCBI): 29260 Conjugate: Unconjugated Form: Liquid Purification Method: Protein A purification UNIPROT ID: Q9QX05 Storage Buffer: PBS with 0.09% sodium azide, pH 7.3. Storage Conditions: Store at 2 - 8°C. Stable for one year after shipment.