Proteintech, CL405-65189, CoraLite® Plus 405 Anti-Mouse CD41 (MWReg30)

Size: 100ug The CD41 (CL405-65189) by Proteintech is a Monoclonal antibody targeting CD41 in FC applications with reactivity to mouse samples CL405-65189 targets CD41 in FC applications and shows reactivity with mouse samples. Tested Applications Positive FC detected in: mouse peripheral blood platelets, mouse splenocytes Recommended dilution Flow Cytometry (FC): FC : 0.5 ug per 10^6 cells in 100 μl suspension Background Information The integrins are a superfamily of cell adhesion receptors that bind to extracellular matrix ligands, cell-surface ligands, and soluble ligands (PMID: 17543136). They are transmembrane αβ heterodimers and at least 24 distinct integrin heterodimers are formed by the combination of 18 α and eight β known subunits (PMID: 17543136; 20029421). In addition to mediating cell adhesion, integrins also play important roles in modulating signal transduction pathways that control cellular responses including migration, proliferation, differentiation, and apoptosis (PMID: 19118207). Integrin alpha-IIb (ITGA2B, CD41) is expressed on platelets, megakaryocytes and some hematopoietic progenitor cells (PMID: 11934866). This protein undergoes post-translational cleavage to yield disulfide linked light beta (25 kDa) and heavy alpha (125 kDa) chains, which join with integrin beta3 (CD61) to form a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. CD41/CD61 is crucial for platelet aggregation through binding of soluble fibrinogen. Specification Tested Reactivity: mouse Host / Isotype: Rat / IgG1, kappa Class: Monoclonal Type: Antibody Immunogen: Mouse platelets Predict reactive species Full Name: integrin alpha 2b GenBank Accession Number: BC120493 Gene Symbol: CD41 Gene ID (NCBI): 16399 RRID: AB_3083839 Conjugate: CoraLite® Plus 405 Fluorescent Dye Excitation/Emission Maxima Wavelengths: 399 nm / 422 nm Form: Liquid Purification Method: Affinity purification UNIPROT ID: Q9QUM0 Storage Buffer: PBS with 0.09% sodium azide, pH 7.3. Storage Conditions: Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment.