Proteintech, CL555-lt, ChromoTek anti-LAG3 recombinant VHH, CoraLite® Plus 555

Size: 150ul CL555-lt targets LAG3 in FC and IF applications and shows reactivity with Human samples. Specification Applications: FC, IF Reactivity: Human Conjugate: CoraLite® Plus 555 Type: Nanobody Class: Recombinant Host: Alpaca Affinity: Picomolar range, below the assay limit (biolayer interferometry) Molecular Weight: 15.141 kDa Form: Liquid Excitation/Emission Maxima Wavelengths: 554 nm / 570 nm RRID: AB_3101917 Storage Buffer: 500 mM NaCl, 10 mM HEPES pH 7.0, 5 mM EDTA, 0.09% sodium azide Storage Condition: Store at -20°C; Shipped at ambient temperature. Background: LAG-3, also known as CD223, is an immune checkpoint molecule that regulates both T-cell activation and homeostasis. LAG-3 is expressed on activated T cells, NK cells, regulatory T cells, and plasmacytoid dendritic cells. It is a CD4-related molecule that binds MHC class II. LAG-3 plays an important role in modulating T cell expansion and function, and blockade of LAG-3 with monoclonal antibodies can augment T cell function. (PMID: 15634887; 21086108; 28783703)