Revvity, 64NPMTTDA, HTRF Human and Mouse Total NPM1 Detection Kit, Control Lysate

Overview
NPM1 (Nucleophosmin 1) is a molecular chaperone involved in cell cycle regulation, ribosome biogenesis, cell proliferation, DNA damage repair, and apoptosis. Its phosphorylation on Thr199 by the CDK2/Cyclin E complex regulates mitosis, centrosome duplication, pre-mRNA processing, and G2/M cell cycle arrest through its interaction with p53/MDM2.
NPM1 functions both as an oncogene and a tumor suppressor. It is frequently overexpressed, altered, and rearranged, or sporadically deleted, in human cancers. NPM1 is also the most frequently mutated gene (NPM1c) in acute myeloid leukemia (AML). Application-Cell Signaling
Automation Compatible-Yes
Brand-HTRF
Detection Modality-HTRF
Molecular Modification-Total
Product Group-Control Lysate
Shipping Conditions-Shipped in Dry Ice
Target-NPM1
Target Class-Phosphoproteins
Target Species-Human Mouse
Technology-TR-FRET
Therapeutic Area-Oncology
Unit Size-1 vial