Revvity, AL3169F, AlphaLISA Human C1q Binding Kit, 5,000 Assay Points

Overview
Complement component 1q, also known as C1q, is a protein complex involved in the complement system. C1q senses antigen/antibody complexes formed with IgG or IgM and binds to antibody Fc via its globular heads. When this occurs, intramolecular rearrangement of the C1 complex is induced, triggering the activation of C1r and C1s proteases and the sequential cleavage of the circulating complement proteins. This leads to the formation of the Membrane Attack Complex (MAC) and to cell lysis. C1q binding measurements are related to the mechanism of action and Fc effector functions of biologics and therapeutic antibodies and utilized for studies in oncology, autoimmune disease, neurology, and infectious disease.
Formats

Our 100 assay point kit allows you to run 100 wells in 96-well format, using a 20 µL reaction volume (5 µL of sample).
Our 500 assay point kit allows you to run 500 wells in 96-well or 384-well format, using a 20 µL reaction volume (5 µL of sample).
Our 5,000 assay point kit allows you to run 5,000 wells in 96-well or 384-well format, using a 20 µL reaction volume (5 µL of sample).

Features

No-wash steps, no separation steps
ELISA alternative technology
Sensitive detection
Small sample volume
Application-Protein-Protein Interaction
Automation Compatible-Yes
Brand-AlphaLISA
Detection Modality-Alpha
Product Group-Kit
Sample Volume-5 µL
Shipping Conditions-Shipped in Blue Ice
Target-C1q
Target Class-Binding Assay
Target Species-Human
Technology-Alpha
Therapeutic Area-Autoimmunity Cardiovascular Immuno-oncology Infectious Disease (non-viral) Inflammation Metabolic Neuroscience Oncology Rare Diseases Respiratory Virology
Unit Size-5,000 assay points