Revvity, NET027X250UC, Thymidine, [Methyl-3H]-, Aqueous Sol, Specific Activity: 20 Ci/mmol, 250 µCi

Overview
250 µCi quantity of [Methyl-3H]-Thymidine in aqueous solution is available for your research. Application of [3H]Thymidine can be found in: carboxy-terminal PTH fragments stimulating incorporation in vascular endothelial cells, quantification of granulocyte-macrophage colony-stimulating factor (GM-CSF) hypersensitivity in juvenile myelomonocytic leukemia (JMML), influence of parasympathetic non-adrenergic, non-cholinergic mechanisms on uptake (rat) in response to mastication, measurement of dendritic cell induced T cell response by intracellular ATP levels and uptake in human immunology, etc.
Special Information: If aqueous solutions of thymidine are stored frozen (-20°C), care should be taken to protect the material from U.V. light during the thawing process to prevent possible dimerization.
When [methyl-3H]thymidine is incorporated into cellular DNA and undergoes radiolytic decomposition, [3H]5-hydroxymethyl-2''-deoxyuridine (HMdU) is formed.* The formation of HMdU through transmutation of [methyl-3H]thymidine occurs at the rate of B-decay, which is 0.017% per day. The transmutation product is not volatile.
*References

S. Apelgot and B. Ekert, J. Chem. Phys. 60, 505 (1963).
K. Fink, R. E. Cline, and R. M. Fink, Anal. Chem., 35, 389 (1963).
Specifications and Criteria for Biochemical Compounds, Third Edition (ISBN 0-309-01917-6), National Academy of Sciences - National Research Council, Washington, D.C. 1972.
G. W. Teebor, K. Frenkel, and M. S. Goldstein, Proc. Natl. Acad. Sci. USA 81, 318 (1984).
H. Tono, S.S. Cohen, J. Biol. Chem. 237, 1271 (1962).
M. Nemer, J. Biol. Chem. 237, 143 (1962). Concentration-1 mCi/mL
Molecular Weight-242.2
Specific Activity-20 Ci/mmol (740 GBq/mmol)
CAS Number-50-89-5
Application-Drug Discovery & Development
Brand-NEN Radiochemicals
Buffer/Solvent-Aqueous solution
Detection Modality-Radiometric
Label Position-Specifically Labeled
Molecular Formula-C10H14N2O5
Packaging-NENSure vial
Radioisotope-3 H
Shipping Information-Shipped Ambient
Shipping Conditions-Shipped Ambient
Special Ordering Information-This is a radioactive product - shipping address must have a license to receive radioactive materials.
Storage Conditions-5°C
Unit Size-250 µCi