Revvity, NET1027250UC, Methylhistamine Dihydrochloride, N-α-[methyl- H]-, 250µCi (9.25MBq)

Overview
α-Methylhistamine is a selective agonist for the histamine H3 receptor. This receptor is a GPCR that is a potential drug target for central nervous system disorders.
We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.
Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.
References for NET1027:

Griebel, G., Pichat, P., Pruniaux, M., Beeské, S., Lopez-Grancha, M., Genet, E., Terranova, J.P., Castro, A., Sánchez, J.A., Black, M., Varty, G. B., Weiner, I., Arad, M., Barak, S., De Levie, A., Guillot, E. (2012), SAR110894, a potent histamine H3-receptor antagonist, displays procognitive effects in rodents, Pharmacology Biochemistry and Behavior, 102 (2): 203-214.
Jin, C. Y., Kalimo, H. and Panula, P. (2002), The histaminergic system in human thalamus: correlation of innervation to receptor expression. European Journal of Neuroscience, 15: 1125–1138. Concentration-1 mCi/ml
Molecular Weight-198
Specific Activity-45 - 90 Ci/mmol (1665 - 3330 GBq/mmol)
CAS Number-6481-48-7
Application-Drug Discovery & Development
Brand-NEN Radiochemicals
Buffer/Solvent-Ethanol : 0.01N hydrochloric acid (70:30)
Detection Modality-Radiometric
Label Position-Specifically Labeled
Molecular Formula-C6H13Cl2N3
Packaging-NENSure vial
Radioisotope-3 H
Receptor-Histamine
Shipping Information-Shipped in Dry Ice
Shipping Conditions-Shipped in Dry Ice
Special Ordering Information-This is a radioactive product - shipping address must have a license to receive radioactive materials.
Storage Conditions--20°C
Therapeutic Area-Inflammation
Unit Size-250 µCi