Revvity, NET1148250UC, Mesulergine, [N-methyl- H]-

Overview
Mesulergine acts as an antagonist at serotonin 5-HT2A and 5-HT2C receptors, and as a partial agonist at dopamine receptors.
We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.
Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.
References for NET1148:

Dhwanil A. Dalwadi, Seongcheol Kim, Shahnawaz M. Amdani, Zhenglan Chen, Ren-Qi Huang, John A. Schetz, Molecular mechanisms of serotonergic action of the HIV-1 antiretroviral efavirenz, In Pharmacological Research, Volume 110, 2016, Pages 10-24.
Daniel Hoyer, Günter Engel, Hans O. Kalkman, Molecular pharmacology of 5-HT1 and 5-HT2 recognition sites in rat and pig brain membranes: Radioligand binding studies with [3H]5-HT, [3H]8-OH-DPAT, (−)[125I]iodocyanopindolol, [3H]mesulergine and [3H]Ketanserin, In European Journal of Pharmacology, Volume 118, Issues 1–2, 1985, Pages 13-23. Concentration-1 mCi/mL
Molecular Weight-362.5
Specific Activity-70 - 87 Ci/mmol (2590 - 3219 GBq/mmol)
CAS Number-64795-35-3
Application-Drug Discovery & Development
Brand-NEN Radiochemicals
Buffer/Solvent-Ethanol
Detection Modality-Radiometric
Label Position-Specifically Labeled
Molecular Formula-C18H26N4O2S
Packaging-NENSure vial
Radioisotope-3 H
Receptor-5-Hydroxytryptamine
Shipping Information-Shipped in dry ice
Shipping Conditions-Shipped in Dry Ice
Special Ordering Information-This is a radioactive product - shipping address must have a license to receive radioactive materials.
Storage Conditions--80°C
Therapeutic Area-CNS & Neurologic
Unit Size-250 µCi