Revvity, NET567250UC, Flunitrazepam, [Methyl- H]-, 250µCi (9.25MBq)

Overview
Flunitrazepam acts as an agonist at GABAA receptors. This receptor is an aionotropic receptor and ligand-gated ion channel. Flunitrazepam is used to treat severe insomnia and has also been used as an anesthetic.
We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.
Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.
References for NET567:

M. Rey, A.S. Veleiro, A.A. Ghini, M.S. Kruse, G. Burton, H. Coirini, Effect of synthetic steroids on GABAA receptor binding in rat brain, In Neuroscience, Volume 290, 2015, Pages 138-146.
Mariana Rey, María Sol Kruse, Lautaro D. Alvarez, Alberto A. Ghini, Adriana S. Veleiro, Gerardo Burton, Héctor Coirini, Neuroprotective action of synthetic steroids with oxygen bridge. Activity on GABAA receptor, In Experimental Neurology, Volume 249, 2013, Pages 49-58. Concentration-1 mCi/ml
Molecular Weight-313.3
Specific Activity-70 - 87 Ci/mmol (2590 - 3219 GBq/mmol)
CAS Number-1622-62-4
Application-Drug Discovery & Development
Brand-NEN Radiochemicals
Buffer/Solvent-Ethanol
Detection Modality-Radiometric
Label Position-Specifically Labeled
Molecular Formula-C16H12FN3O3
Packaging-NENSure vial
Radioisotope-3 H
Receptor-Benzodiazepine GABAA
Shipping Information-Shipped Ambient
Shipping Conditions-Shipped Ambient
Special Ordering Information-This is a radioactive product - shipping address must have a license to receive radioactive materials.
Storage Conditions--20°C
Therapeutic Area-CNS & Neurologic
Unit Size-250 µCi