Revvity, NET636250UC, Scopolamine Methyl Chloride, [N-methyl- H]-, 250µCi (9.25MBq)

Overview
250µCi quantities of Scopolamine Methyl Chloride, [N-methyl-3H]-, are available for your research. Scopolamine is a natural product antagonist of muscarinic acetylcholine receptors, and is used to treat motion sickness and nausea.
We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.
Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.
References for NET636:

Michael Salmon, Mark A. Luttmann, James J. Foley, Peter T. Buckley, Dulcie B. Schmidt, Miriam Burman, Edward F. Webb, Christopher J. DeHaas, Charles J. Kotzer, Victoria J. Barrett, Robert J. Slack, Henry M. Sarau, Michael R. Palovich, Dramane I. Lainé, Douglas W. P. Hay and William L. Rumsey, Pharmacological Characterization of GSK573719 (Umeclidinium): A Novel, Long-Acting, Inhaled Antagonist of the Muscarinic Cholinergic Receptors for Treatment of Pulmonary Diseases, Journal of Pharmacology and Experimental Therapeutics May 2013, 345 (2): 260-270.
Weng-Keong Loke, Meng-Kwoon Sim, Mei-Lin Go, O-Substituted derivatives of pralidoxime: muscarinic properties and protection against soman effects in rats, European Journal of Pharmacology, 2002, 442 (3): 279-287. Concentration-1 mCi/ml
Molecular Weight-353.8
Specific Activity-70 - 87 Ci/mmol (2590 - 3219 GBq/mmol)
CAS Number-155-41-9
Application-Drug Discovery & Development
Brand-NEN Radiochemicals
Buffer/Solvent-Ethanol
Detection Modality-Radiometric
Label Position-Specifically Labeled
Molecular Formula-C18H24NO4Cl
Packaging-NENSure vial
Radioisotope-3 H
Receptor-Acetylcholine (Muscarinic)
Shipping Information-Shipped in Dry Ice
Shipping Conditions-Shipped in Dry Ice
Special Ordering Information-This is a radioactive product - shipping address must have a license to receive radioactive materials.
Storage Conditions--20°C
Therapeutic Area-Cardiovascular CNS & Neurologic Gastrointestinal
Unit Size-250 µCi