Revvity, NET648250UC, Enkephalin (2-D-Alanine-5-D-Leucine), [Tyrosyl-3,5- H(N)]-, 250µCi (9.25MBq)

Overview
DADLE acts as an agonist at delta opioid receptors (DOR), but has also been shown to bind mu opioid receptors (MOR). These receptors are a group of GPCRs that are potential drug targets for pain and drug addiction.
We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.
Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.
References for NET648:

Vošahlíková, M., Jurkiewicz, P., Roubalová, L. et al. (2014), High- and low-affinity sites for sodium in δ-OR-Gi1α (Cys351-Ile351) fusion protein stably expressed in HEK293 cells; functional significance and correlation with biophysical state of plasma membrane. Naunyn-Schmiedeberg's Arch Pharmacol, 387: 487.
Bourova, L., Kostrnova, A., Hejnova, L., Moravcova, Z., Moon, H.-E., Novotny, J., Milligan, G. and Svoboda, P. (2003), δ-Opioid receptors exhibit high efficiency when activating trimeric G proteins in membrane domains. Journal of Neurochemistry, 85: 34–49. Concentration-1 mCi/ml
Molecular Weight-569.7
Specific Activity->30Ci/mmol (>1110 GBq/mmol)
CAS Number-94825-57-7
Application-Drug Discovery & Development
Brand-NEN Radiochemicals
Buffer/Solvent-Ethanol
Detection Modality-Radiometric
Label Position-Nominally Labeled
Molecular Formula-C29H39N5O
Packaging-NENSure vial
Radioisotope-3 H
Receptor-Opioid
Shipping Information-Shipped in dry ice
Shipping Conditions-Shipped in Dry Ice
Special Ordering Information-This is a radioactive product - shipping address must have a license to receive radioactive materials.
Storage Conditions--20°C
Therapeutic Area-CNS & Neurologic Inflammation Pain
Unit Size-250 µCi