Revvity, NET678005MC, Norepinephrine, Levo-[ring-2,5,6- H]-, 5mCi (185MBq)

Overview
5 mCi quantities of Norepinephrine, Levo-[ring-2,5,6-3H]-. Norepinephrine (NA) is a neurotransmitter and hormone that increases heart rate and blood pressure, and is involved in the fight-or-flight response. It is widely used to treat low blood pressure.
We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.
Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.
References for NET678:

Auch-Schwelk, W., Starke, K. and Steppeler, A. (1983), Experimental conditions required for the enhancement by α-adrenoceptor antagonists of noradrenaline release in the rabbit ear artery. British Journal of Pharmacology, 78: 543–551.
Bryan-Lluka, L., Siebert, G. & Pond, S. (1999) Potencies of haloperidol metabolites as inhibitors of the human noradrenaline, dopamine and serotonin transporters in transfected COS-7 cells. Naunyn-Schmiedeberg's Arch Pharmacol, 360: 109. Concentration-1 mCi/ml
Molecular Weight-169.2
Specific Activity->20 Ci/mmol (>740 GBq/mmol)
CAS Number-51-41-2
Application-Drug Discovery & Development
Brand-NEN Radiochemicals
Buffer/Solvent-0.2N acetic acid : ethanol solution, (9:1)
Detection Modality-Radiometric
Label Position-Specifically Labeled
Molecular Formula-C8H11NO3
Packaging-NENSure vial
Radioisotope-3 H
Receptor-Adrenoceptors
Shipping Information-Shipped in Dry Ice
Shipping Conditions-Shipped in Dry Ice
Special Ordering Information-This is a radioactive product - shipping address must have a license to receive radioactive materials.
Storage Conditions--20°C
Therapeutic Area-Cardiovascular CNS & Neurologic Metabolic Disorders
Unit Size-5 mCi