Revvity, NET722250UC, Rauwolscine, [Methyl- H]-, 250µCi (9.25MBq)

Overview
Rauwolscine acts as an α2-adrenergic receptor antagonist.
We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.
Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.
References for NET722:

T. Nakagawa, K. Nagayasu, N. Nishitani, H. Shirakawa, K. Sekiguchi, Y. Ikarashi, Y. Kase, S. Kaneko, Yokukansan inhibits morphine tolerance and physical dependence in mice: The role of α2A-adrenoceptor, Neuroscience, Volume 227, 2012, Pages 336-349.
Ignacio Javier Chiesa, Lilian Fedra Castillo, Isabel Alicia Lüthy, Contribution of α2-adrenoceptors to the mitogenic effect of catecholestrogen in human breast cancer MCF-7 cells, The Journal of Steroid Biochemistry and Molecular Biology, Volume 110, Issues 1–2, 2008, Pages 170-175. Concentration-1 mCi/ml
Molecular Weight-354.4
Specific Activity->70 Ci/mmol (>2590 GBq/mmol)
CAS Number-131-03-3
Application-Drug Discovery & Development
Brand-NEN Radiochemicals
Buffer/Solvent-Ethanol solution containing 0.25% ascorbic acid
Detection Modality-Radiometric
Label Position-Specifically Labeled
Molecular Formula-C21H26N2O3
Packaging-NENSure vial
Radioisotope-3 H
Receptor-Adrenoceptors
Shipping Information-Shipped in dry ice
Shipping Conditions-Shipped in Dry Ice
Special Ordering Information-This is a radioactive product - shipping address must have a license to receive radioactive materials.
Storage Conditions--80°C
Therapeutic Area-Cardiovascular
Unit Size-250 µCi