Revvity, NET757001MC, Ro 15-1788, [N-Methyl- H]-, 1 mCi

Overview
1 mCi quantities of Ro 15-1788, [N-Methyl-3H]-, are available for research. Ro 15-1788 acts as a selective benzodiazepine antagonist. It is used to treat benzodiazepine overdoses and reverse anesthesia.
We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.
Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.
References for NET757:

Benke D, Cicin-Sain A, Mertens S, Mohler H. Immunochemical identification of the alpha 1- and alpha 3-subunits of the GABAA-receptor in rat brain. J Recept Res. 1991;11(1-4):407-24.
Goeders, N., Kuhar, M.J. Benzodiazepine receptor binding invivo with [3H]-Ro 15-1788, Life Sciences, Volume 37, Issue 4, 1985, Pages 345-355. Concentration-1 mCi/ml
Molecular Weight-303
Specific Activity->70 Ci/mmol (>2590 GBq/mmol)
CAS Number-78755-81-4
Application-Drug Discovery & Development
Brand-NEN Radiochemicals
Buffer/Solvent-Ethanol
Detection Modality-Radiometric
Label Position-Specifically Labeled
Molecular Formula-C15H14FN3O3
Packaging-NENSure vial
Radioisotope-3 H
Receptor-Benzodiazepine GABAA
Shipping Information-Solvent- ethanol
Shipping Conditions-Shipped in Dry Ice
Special Ordering Information-This is a radioactive product - shipping address must have a license to receive radioactive materials.
Storage Conditions--80°C
Therapeutic Area-CNS & Neurologic
Unit Size-1 mCi