Revvity, NET886250UC, TCP, [Piperdyl-3,4-3H(N)]-, 250 µCi

Overview
TCP acts as an antagonist at N-methyl-D-aspartate receptor (NMDA receptors), and is a dissociative anesthetic drug with hallucinogenic effects.
We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.
Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.
References for NET886:

Z. Kawakami, H. Kanno, T. Ueki, K. Terawaki, M. Tabuchi, Y. Ikarashi, Y. Kase, Neuroprotective effects of yokukansan, a traditional japanese medicine, on glutamate-mediated excitotoxicity in cultured cells, Neuroscience, Volume 159, Issue 4, 2009, Pages 1397-1407.
Matthew A. Sills, Graham Fagg, Mario Pozza, Christof Angst, Derek E. Brundish, Stephen D. Hurt, E. Jay Wilusz, Michael Williams, [3H]CGP 39653: a new N-methyl-D-aspartate antagonist radioligand with low nanomolar affinity in rat brain, European Journal of Pharmacology, Volume 192, Issue 1, 1991, Pages 19-24. Concentration-1 mCi/ml
Molecular Weight-249.24
Specific Activity-40 - 60 Ci/mmol (1480 - 2220 GBq/mmol)
CAS Number-96-18-4
Application-Drug Discovery & Development
Brand-NEN Radiochemicals
Buffer/Solvent-Ethanol
Detection Modality-Radiometric
Label Position-Nominally Labeled
Molecular Formula-C15H23NS
Packaging-NENSure vial
Radioisotope-3 H
Receptor-Glutamate
Shipping Information-Shipped in dry ice
Shipping Conditions-Shipped in Dry Ice
Special Ordering Information-This is a radioactive product - shipping address must have a license to receive radioactive materials.
Storage Conditions--20°C
Therapeutic Area-CNS & Neurologic
Unit Size-250 µCi