Revvity, NET914250UC, Methyl-4-Phenylpyridinium Acetate, N-[Methyl- H]-, MPP (+), 250µCi (9.25MBq)

Overview
250 µCi quantities of Methyl-4-Phenylpyridinium Acetate, N-[Methyl-3H]-, MPP (+), are available for your research. MPP+ is a dopaminergic selective neurotoxin, and has been used to study Parkinson's disease.
We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.
Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.
References for NET914:

Kristufek, D., Rudorfer, W., Pifl, C. and Huck, S. (2002), Organic cation transporter mRNA and function in the rat superior cervical ganglion. The Journal of Physiology, 543: 117–134.
Russ, H., Gliese, M., Sonna, J. et al. The extraneuronal transport mechanism for noradrenaline (uptake2) avidly transports 1-methyl-4-phenylpyridinium (MPP+). Naunyn-Schmiedeberg's Arch Pharmacol (1992) 346: 158. Concentration-1 mCi/ml
Molecular Weight-229.3
Specific Activity->70 Ci/mmol (>2590 GBq/mmol)
CAS Number-36913-39-0
Application-Drug Discovery & Development
Brand-NEN Radiochemicals
Buffer/Solvent-Ethanol
Detection Modality-Radiometric
Label Position-Specifically Labeled
Molecular Formula-C14H15NO2
Packaging-NENSure vial
Radioisotope-3 H
Receptor-Dopamine Transporter
Shipping Information-Shipped in dry ice
Shipping Conditions-Shipped in Dry Ice
Special Ordering Information-This is a radioactive product - shipping address must have a license to receive radioactive materials.
Storage Conditions--20°C
Therapeutic Area-CNS & Neurologic
Unit Size-250 µCi