Revvity, NET918250UC, GBR 12935, [Propylene-2,3- H]-, 250µCi (9.25MBq)

Overview
GBR 12935 acts as an antagonist of the dopamine transporter, and is used in animal research into Parkinson's disease and dopamine pathways in the brain.
We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.
Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.
References for NET918:

Paul Berger, John D. Elsworth, Jorge Arroyo, Robert H. Roth, Interaction of [3H]GBR 12935 and GBR 12909 with the dopamine uptake complex in nucleus accumbens, In European Journal of Pharmacology, Volume 177, Issues 1–2, 1990, Pages 91-94.
Peter H. Andersen, J.Aas Jansen, Erik B. Nielsen, [3H]GBR 12935 binding in vivo in mouse brain: labelling of a piperazine acceptor site, In European Journal of Pharmacology, Volume 144, Issue 1, 1987, Pages 1-6. Concentration-1 mCi/ml
Molecular Weight-414.6
Specific Activity-≥20 Ci/mmol (≥740 GBq/mmol)
CAS Number-67469-81-2
Application-Drug Discovery & Development
Brand-NEN Radiochemicals
Buffer/Solvent-Ethanol
Detection Modality-Radiometric
Label Position-Specifically Labeled
Molecular Formula-C28H34N2O
Packaging-NENSure vial
Radioisotope-3 H
Receptor-Dopamine Transporter
Shipping Information-Shipped in dry ice
Shipping Conditions-Shipped in Dry Ice
Special Ordering Information-This is a radioactive product - shipping address must have a license to receive radioactive materials.
Storage Conditions--20°C
Therapeutic Area-CNS & Neurologic
Unit Size-250 µCi