Revvity, NET950250UC, Ryanodine, [9,21- H(N)]-, 250µCi (9.25MBq)

Overview
Ryanodine is a plant alkaloid and natural ligand for the ryanodinen receptor (RyR), a class of calcium channels (Ca2+ channels).
We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.
Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.
References for NET950:

Araki, T., Kato, H., Shuto, K., Oshima, Y. and Itoyama, Y. (1998), Postischemic changes of [3H]nimodipine and [3H]ryanodine binding in the gerbil striatum and hippocampus. European Journal of Neurology, 5: 195–201. Concentration-0.1 mCi/ml
Molecular Weight-493.5
Specific Activity-50 - 100 Ci/mmol (1850 - 3700 GBq/mmol)
CAS Number-15662-33-6
Application-Drug Discovery & Development
Brand-NEN Radiochemicals
Buffer/Solvent-Ethanol
Detection Modality-Radiometric
Label Position-Nominally Labeled
Molecular Formula-C25H35NO9
Packaging-NENSure vial
Radioisotope-3 H
Receptor-Calcium
Shipping Information-Shipped in dry ice
Shipping Conditions-Shipped in Dry Ice
Special Ordering Information-This is a radioactive product - shipping address must have a license to receive radioactive materials.
Storage Conditions--20°C
Therapeutic Area-CNS & Neurologic Musculoskeletal
Unit Size-250 µCi