Revvity, NET974001MC, Cyclopentyl-1,3-Dipropylxanthine, 8-[Dipropyl-2,3- H(N)]-, 1mCi (37MBq)

Overview
8-Cyclopentyl-1,3-dipropylxanthine (DPCPX, PD-116,948) acts as an antagonist at the adenosine A1 receptor. This receptor is part of a group of adenosine GPCRs, is implicated in sleep promotion and breathing, and is a potential drug target for sleep apnea.
We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.
Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.
References for NET974:

Schetz, J. A. and Sibley, D. R. (1997), Zinc Allosterically Modulates Antagonist Binding to Cloned D1 and D2 Dopamine Receptors. Journal of Neurochemistry, 68: 1990–1997.
Qinye Dong, Jennifer Schuchman, Gale B. Carey, Characterization of the swine adipocyte A1 adenosine receptor using an optimized assay system, In Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology, Volume 108, Issue 3, 1994, Pages 269-280. Concentration-1 mCi/ml
Molecular Weight-304
Specific Activity->80 Ci/mmol (>2960 GBq/mmol)
CAS Number-102146-07-6
Application-Drug Discovery & Development
Brand-NEN Radiochemicals
Buffer/Solvent-Ethanol
Detection Modality-Radiometric
Label Position-Nominally Labeled
Molecular Formula-C16H24N4O2
Packaging-NENSure vial
Radioisotope-3 H
Receptor-Adenosine
Shipping Information-Shipped in dry ice
Shipping Conditions-Shipped in Dry Ice
Special Ordering Information-This is a radioactive product - shipping address must have a license to receive radioactive materials.
Storage Conditions--20°C
Therapeutic Area-Cardiovascular CNS & Neurologic Inflammation
Unit Size-1 mCi