Revvity, NEV10040, IVISense Folate Receptor 680 Fluorescent Probe (FolateRSense 680)

Overview
Folate receptors are a family of cell surface receptors that bind the essential vitamin folic acid (folate, vitamin B9). These receptors are upregulated in highly metabolic cells and over-expression of FRA protein is associated with tumor growth, as uptake of folic acid is a necessary part of tumor metabolism.
Folate is essential for cellular metabolism and DNA synthesis, methylation, and repair. High metabolic cells such as proliferating cancer cells have increased demand for folate to maintain their accelerated DNA synthesis; thus overexpression of folate receptors (FRs) is a recognized biomarker of many tumors, though tumors can differ in their dependence on folate metabolism. Brand-IVISense
Fluorescent Agent Type-Targeted
Imaging Modality-Fluorescence
Shipping Conditions-Shipped Ambient
Specificity-Folate receptor
Storage Conditions-+2 to +8 °C
Therapeutic Area-Arthritis Cardiovascular Inflammation Oncology Pulmonary
Unit Size-1 vial (10 doses)
Wave Length-680 nm