Revvity, NEX306050UC, Sauvagine, [ I]-Tyr ], 50µCi

Overview
50 µCi Quantities of Sauvagine, [125I]-Tyr0] are available for your research.
We offer radioligands and radiolabeled biomolecules to use as tracers, for radioimmunoassays (RIAs), for autoradiographic visualization, or for performing saturation and competition radioligand binding assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radiolabeled compounds is fully characterized for pharmacological action and validated in binding assays.
Radiochemicals remain the most sensitive method for probing binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.
References for NEX306:

Oakley, R.H., Olivares-Reyes, J.A., Hudson, C.C., Flores-Vega, F., Dautzenberg, F.M., Hauger, R.L. (2007), Carboxyl-terminal and intracellular loop sites for CRF1 receptor phosphorylation and beta-arrestin-2 recruitment: a mechanism regulating stress and anxiety responses. Am J Phsiol Regul Integr Comp Physiol., 293 (1): R209-222.
Million, M., Grigoriadis, D.E., Sullivan, S., Crowe, P.D., McRoberts, J.A., Zhou, H., Saunders, P.R., Maillot, C., Mayer, E.A., Taché, Y. (2003), A novel water-soluble selective CRF1 receptor antagonist, NBI 35965, blunts stress-induced visceral hyperalgesia and colonic motor function in rats. Brain Res, 985 (1): 32-42. Molecular Weight-4778
Specific Activity-2200 Ci/mmol (81.4 TBq/mmol)
CAS Number-74434-59-6
Application-Drug Discovery & Development
Brand-NEN Radiochemicals
Buffer/Solvent-Acetonitrile : water (35:65), 0.05M mercaptoethanol, 0.2% TFA, and 0.2% BSA
Detection Modality-Radiometric
Fresh Lot Days-Fourth Monday of each month
Label Position-Nominally Labeled
Molecular Formula-C202H346N56O63S
Packaging-NENSure vial
Radioisotope-125 I
Receptor-Corticotropin-releasing factor
Shipping Information-Shipped Ambient
Shipping Conditions-Shipped Ambient
Special Ordering Information-This is a radioactive product - shipping address must have a license to receive radioactive materials.
Storage Conditions-4°C
Therapeutic Area-CNS & Neurologic Inflammation
Unit Size-50 µCi