Revvity, NEX420050UC, Insulin (human, recombinant), [ I], 50 µCi

Overview
50 µCi Quantities of Insulin (human, recombinant), [125I] are available for your research.
We offer radioligands and radiolabeled biomolecules to use as tracers, for radioimmunoassays (RIAs), for autoradiographic visualization, or for performing saturation and competition radioligand binding assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radiolabeled compounds is fully characterized for pharmacological action and validated in binding assays.
Radiochemicals remain the most sensitive method for probing binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.
References for NEX420:

Cascieri, M. A. et al. Mutants of human insulin-like growth factor I with reduced affinity for the type 1 insulin-like growth factor receptor. Biochemistry 27, 3229–3233 (1988).
Chou, Y.-H., Kuo, W.-L., Rosner, M. R., Tang, W.-J. & Goldman, R. D. Structural changes in intermediate filament networks alter the activity of insulin-degrading enzyme. The FASEB Journal 23, 3734–3742 (2009). Molecular Weight-5931.6
Specific Activity-2200 Ci/mmol (81.4 TBq/mmol)
CAS Number-11061-68-0
Application-Drug Discovery & Development
Brand-NEN Radiochemicals
Buffer/Solvent-Lyophilized
Detection Modality-Radiometric
Fresh Lot Days-Second Monday of each Month
Host Species-Human
Label Position-Nominally Labeled
Packaging-NENSure vial
Radioisotope-125 I
Receptor-Insulin
Shipping Information-Shipped on dry ice
Shipping Conditions-Shipped in Dry Ice
Special Ordering Information-This is a radioactive product - shipping address must have a license to receive radioactive materials.
Storage Conditions-4°C
Therapeutic Area-Diabetes Obesity
Unit Size-50 µCi