Revvity, PART53BP111, PhenoVue anti-53BP1 - Rat IgG2a Antibody, 100x

Overview
DNA damage ranges from single-strand breaks (SSBs) to double-strand breaks (DSBs) and complex base modifications. DSBs are the most harmful, leading to genomic instability or cell death if unrepaired. Cells activate the DNA damage response (DDR) to detect and repair damage which is crucial for studying genome stability, assessing cytotoxic agents, and developing anticancer drugs. DSBs trigger the relocalization of key DDR proteins (MRE11/NBS1/RAD50, MDC1, 53BP1, BRCA1) to nuclear foci, where they interact with γ-H2AX. 53BP1 promotes canonical non-homologous end joining (C-NHEJ) over homologous recombination and alternative NHEJ.
The PhenoVue anti-53BP1 – rat IgG2a antibody, part of the PhenoVue DNA Damage Response Staining Kit (PDDR11), supports imaging and high-content analysis applications. Form-Solution
Application-High Content Imaging Microscopy
Assay Points-1 x 384-well microplate
Brand-PhenoVue™
Host Species-Rat
Product Group-Antibody
Quantity-1 x 100 µL
Sample Type-Fixed samples only
Shipping Conditions-Shipped in Dry Ice
Storage Conditions--16 °C or below, protected from light
Target Species-Human Mouse (predicted)
Type-Individual reagent